Revealed Where The Infection Lurks In Recurrent Cystitis

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Revealed Where The Infection Lurks In Recurrent Cystitis
Revealed Where The Infection Lurks In Recurrent Cystitis

Video: Revealed Where The Infection Lurks In Recurrent Cystitis

Отличия серверных жестких дисков от десктопных
Video: Recurrent Cystitis/Urinary Tract Infections-Learn the Fascinating Ancestral Tip of B.Coli 2023, February
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Revealed where the infection lurks in recurrent cystitis

It turned out that the causative agents of urinary tract infections can hide inside the cells of the vaginal mucosa. They are able to leave this shelter to re-infect the bladder.

Revealed where the infection lurks in recurrent cystitis
Revealed where the infection lurks in recurrent cystitis

Photo: lenahelfinger / Jerzy Górecki / Pixabay

It appears that the ability of the bacteria that causes it to hide inside the cells of the vaginal epithelium helps the development of recurrent cystitis. This is shown by a study published in Nature Communications.

It is known that many infections are chronic due to the fact that their pathogens have reservoirs in the body in which they can safely persist for some time. Infection of the urinary system (its most famous manifestation is cystitis) often becomes recurrent: in about 40% of infected people, a second disease develops within six months. The same bacteria strains are usually responsible for repeated cases. But the mechanisms for recurrent infection are poorly known.

First, scientists from the Department of Urology at Vanderbilt University Medical Center studied the course of recurrent cystitis in mice. They found that Escherichia coli (the most common cause of cystitis) can not only adhere to the vaginal epithelium (the outer layer of the mucous membrane), but also penetrate it. The authors showed that this bacterium can persist for a long time inside the cells of the vaginal mucosa after the animals have suffered cystitis. Re-seeding with bacteria in the bladder, which causes cystitis to recur, occurs when they leave these cells.

Most importantly, the scientists tested the data from these experiments by examining people. They took samples of the vaginal epithelium from women suffering from recurrent cystitis. The researchers found bacteria in mucosal cells where they were protected from external influences. Scientists are confident that bacteria can leave this shelter to re-infect the bladder.

The press release states that scientists have discovered "a new stage in the progression of urinary tract infection with a unique method of penetration into the cells of the vagina, creating a reservoir for the development of reinfection."

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