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Video: Psoriasis Increases The Risk Of Alzheimer's Disease
Psoriasis increases the risk of Alzheimer's disease
Korean scientists have found that chronic inflammatory conditions in psoriasis can have powerful negative effects on the nervous system.
Researchers at the Catholic University of Korea in Seoul used data from the Korea National Health Insurance System to identify 535,927 people with psoriasis and 2,679,635 people by age and sex without psoriasis who had at least three health screenings between 2008 and 2014. The risk of Alzheimer's disease (AD) was assessed in two groups.
During the median follow-up period of 3.35 years, 50,209 cases of Alzheimer's disease were examined. Scientists have found that patients with psoriasis have a significantly increased risk of developing AD compared to a control group without psoriasis in adjusted models.
At the same time, the risk of developing the disease was significantly increased in those patients who did not receive systemic therapy for psoriasis. In addition, the association between psoriasis and Alzheimer's disease was more pronounced in middle-aged patients (40–64 years) compared with elderly patients (65 years and older). According to scientists, this may be due to the fact that aging helps to reduce the immune function of regulatory T cells, thereby reducing inflammation and suppressing the development of inflammatory skin diseases.
"These results indicate that chronic inflammatory conditions in psoriasis may have important effects on the nervous system and, therefore, increase the risk of developing Alzheimer's disease," the authors write. According to them, taking systemic anti-inflammatory drugs reduces inflammation of neuronal cells and general inflammation in the body, thus reducing the risk of this disease in patients with psoriasis.