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Video: How Excess Fat Triggers Diabetes
How excess fat triggers diabetes
For the first time, scientists have been able to trace how fats that have accumulated under the skin and in the liver can enter the pancreas and provoke diabetes.
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For the first time, scientists have been able to trace how fats that have accumulated under the skin and in the liver can enter the pancreas and provoke diabetes. They talked about their discovery in the journal Cell Metabolism.
Scientists observed a group of patients who were able to achieve remission with type 2 diabetes. In the earlier DiRECT study, they achieved normal blood sugar levels through exercise and weight control. The authors focused on a small group of patients who relapsed within two years.
How fat was distributed in the body of patients, scientists investigated using modern methods of visualization and monitoring of blood parameters.
“We found that when a person accumulates too much fat under the skin, it spreads to other parts of the body. The amount of fat that can be stored under the skin differs from person to person,”said study author Professor Roy Taylor of Newcastle University.
When fat cannot remain only under the skin, it enters, including the liver and pancreas, scientists have found. This helps to turn off certain genes that are responsible for the production of insulin. As a result, diabetes is returning.
In the study, scientists were able to prove that in people to whom the manifestations of diabetes returned, fats that accumulated in the liver entered the bloodstream, and then were found in the pancreas.
“This means that now we can now view diabetes as a condition in which a person has accumulated more fat than the body can control,” added Taylor. He emphasized that this also means that diet and persistence can be of great help in the prevention and treatment of diabetes.