HIV Vaccine With Over 50% Efficiency May Appear As Early As 2021

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HIV Vaccine With Over 50% Efficiency May Appear As Early As 2021
HIV Vaccine With Over 50% Efficiency May Appear As Early As 2021

Video: HIV Vaccine With Over 50% Efficiency May Appear As Early As 2021

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HIV vaccine with over 50% efficiency may appear as early as 2021

Scientists predict that in 2021 the world may receive the first HIV vaccine that will be effective enough for mass use. Three vaccines are currently in the final stages of research. Despite the fact that the final data has not yet been received, experts are not afraid to voice unprecedentedly optimistic expectations.

HIV vaccine with over 50% efficiency may appear as early as 2021
HIV vaccine with over 50% efficiency may appear as early as 2021

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Scientists predict that in 2021 the world may receive the first HIV vaccine that will be effective enough for mass use. Three vaccines are currently in the final stages of research. Despite the fact that the final data has not yet been received, experts are not afraid to voice unprecedentedly optimistic expectations.

The first effective vaccine

In the HVTN 702 study, scientists are testing the effectiveness of the vaccine, which is a modification of the experimental drug RV144. In 2009, it did not demonstrate sufficient effectiveness and did not hit the market. At the same time, until now, it was the only vaccine that has demonstrated efficacy: the degree of protection was approximately 30%.

HVTN 702 is the first study of an HIV vaccine since the RV144 “failure”. The US National Institute of Allergy and Infectious Diseases (NIAID) indicates that the modifications made to it "are intended to provide greater protection." The results of the work will be announced in late 2020 or early 2021. This vaccine is designed primarily for strains that are common in southern Africa.

Partial efficiency is a huge success

Even a partially effective vaccine is "a huge breakthrough that has the power to change the trajectory of emission," Dr. Susan Buchbinder, director of the joint HIV research program at the San Francisco Department of Health, told NBC News. She is also leading research on two other HIV vaccines, Imbokodo and Mosaico.

Dr. Anthony Fauci, director of the NIAID, has long been a proponent of a vaccine that is at least 50% effective. Now he says he is more convinced than ever that even a partially effective vaccine should be adopted. In his opinion, if you add a vaccine, the effectiveness of which is 50-60%, to the successfully used prevention methods, this can radically change the situation.

Mosaic vaccines

The second current study is Imbokodo. It is attended only by women and is held in five South African countries. The test vaccine works differently from the HVTN study. It is a mosaic vector vaccine, meaning it includes protein fragments that contain all the major strains of the virus. Therefore, the protection that it can provide in the future will be broader.

The vaccine was proven safe in 2018, and vaccination with rhesus mamak gave protection in 67% of cases.

A third study, Mosaico, is also investigating a mosaic vaccine. She was first vaccinated in November 2019. The researchers also plan to include 3,800 gay and transgender men in this study. Its results are expected to be announced in 2023.

Vaccine trials are sometimes interrupted on the basis of intermediate data, because of apparent ineffectiveness, or, conversely, if the evidence of benefit is sufficient. All three studies are considered promising by scientists. Based on current information, none of them are in danger of premature termination.

Dr. Fauci notes that all of the experimental vaccines have a relatively complex regimen, so their use can take some effort. The largely similar vaccines Imbokodo and Mosaico require six injections. In the last two visits, a vaccine is administered, the composition of which is somewhat different from those introduced in previous doses. Fauci emphasizes that such a vaccine could be the first step towards more effective and easier-to-use drugs.

December 1 was World AIDS Day. A few days earlier, the Russian Ministry of Health proposed a new bill that prohibits the dissemination of false information about the impact of HIV infection on health and calls for the refusal of its diagnosis and treatment. You can find out what dangerous myths HIV dissidents spread from our material.

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