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Video: Scientists Have Named The Best Time To Take Drugs Against Hypertension
Scientists have named the best time to take drugs against hypertension
Taking antihypertensive drugs at bedtime provided better blood pressure control compared to taking drugs in the morning. Accordingly, the risk of developing cardiovascular disease and death was reduced.
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According to the Hygia Chronotherapy Trial, conducted by a network of Spanish medical centers and published in the European Heart Journal, blood pressure medications are preferred before bedtime rather than in the morning.
The study is the largest of its kind. In the period from 2008 to 2018, 19084 patients aged 18 and older with a diagnosis of hypertension took part in it. They took their medication when they woke up or before going to bed, and their blood pressure was monitored for 48 hours on an outpatient basis at least once a year. The choice of drugs was made by the participating physicians according to current clinical practice.
The median follow-up period was 6.3 years. During this time, 1,752 patients died of cardiovascular problems or suffered myocardial infarction, stroke, heart failure, or coronary revascularization (a surgical procedure to unblock narrowed arteries).
“The current guidelines for the treatment of hypertension do not mention or recommend any preferred treatment times. Morning intake was the most common medical recommendation based on a false target to lower morning blood pressure,”said study lead author Professor Ramon C. Hermida of the University of Vigo.
Although there have been no studies to support a reduction in the risk of cardiovascular disease with antihypertensive therapy in the morning.
The researchers found that patients who took the medication before bed had a 45% lower risk of death or myocardial infarction, stroke, heart failure, or conditions requiring coronary revascularization, compared with patients who took the medication upon waking. Data were adjusted for factors potentially influencing the results - age, gender, type 2 diabetes, kidney disease, smoking, and cholesterol.
The risk of death from heart or blood vessel problems was reduced by 66%, the risk of myocardial infarction by 44%, heart failure by 42%, stroke by 49%, and the likelihood of needing coronary revascularization by 40%.
“Mean systolic blood pressure during sleep is the most significant and independent indicator of the risk of cardiovascular disease, regardless of blood pressure measurements taken while awake or when visiting a doctor,” said Ramon K. Ermida.
Scientists believe that round-the-clock ambulatory blood pressure monitoring should become the recommended method for diagnosing true hypertension and assessing the risk of cardiovascular diseases.
Limitations of the study include the need to test the results in other ethnic groups, as well as for people working in shifts, since all participants adhered to a daily activity and night sleep regimen.
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