Table of contents:
Video: Scientists Have Discovered The Causes Of Age-related Weight Gain
Scientists have discovered the causes of age-related weight gain
With aging, the rate of lipid metabolism in adipose tissue slows down, leading to weight gain, even if there is no change in diet or physical activity, Swedish and French scientists have found.
Photo: pixabay.com /
Controlling your weight becomes more difficult with age. The reason for this was revealed by a new joint study of the Karolinska Institute, Uppsala University and the University of Lyon - in the process of aging, lipid metabolism in adipose tissue slows down, contributing to weight gain, even nutrition or physical activity remains at the same level. The study is published in Nature Medicine.
Scientists examined the fat cells of 54 men and women for an average of 13 years. During this time, all participants, regardless of weight gain or loss, showed a decrease in lipid metabolism in adipose tissue - the rate of excretion and storage of lipids (or fats) in adipose cells. According to the data obtained, if this is not compensated for by reducing the daily calorie intake, weight increases by an average of 20%.
The researchers also studied lipid metabolism in 41 women after bariatric surgery (surgery to reshape the stomach, a treatment for obesity and related diseases) and found out how the rate of lipid metabolism affects the ability to maintain weight for four to seven years after surgery. According to the results, the acceleration of lipid metabolism and preservation of weight occurred only at low values before surgery. The researchers believe these women had more opportunities to speed up lipid metabolism than the high rates before surgery.
“The results indicate for the first time that processes in our adipose tissue regulate changes in body weight during aging in a way that is independent of other factors. This could open up new approaches to the treatment of obesity,”said Peter Arner, one of the main authors of the study.
As previous studies have shown and confirmed the results obtained, one of the ways to accelerate lipid metabolism in adipose tissue is to increase the load. The scientists noted that the long-term results of weight loss surgery would improve when combined with increased physical activity.
“Obesity and related diseases have become a global problem. Understanding lipid dynamics and what regulates fat mass in humans has never been more relevant,”said Kirsty Spalding, one of the main co-authors of the study.