Scientists Talked About Successful Innovations In The Treatment Of Marshal Zhukov From Stroke

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Scientists Talked About Successful Innovations In The Treatment Of Marshal Zhukov From Stroke
Scientists Talked About Successful Innovations In The Treatment Of Marshal Zhukov From Stroke
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Scientists talked about successful innovations in the treatment of Marshal Zhukov from stroke

Russian scientists spoke about one of the first cases of thrombolytic therapy, which was carried out more than 50 years ago. The patient was Marshal of the USSR Georgy Zhukov, the group of doctors was led by Evgeny Chazov. The clinical case is published in the European Heart Journal. Previously, only their memoirs were known about him.

Scientists talked about successful innovations in the treatment of Marshal Zhukov from stroke
Scientists talked about successful innovations in the treatment of Marshal Zhukov from stroke

Photo: Wikimedia Commons /

Russian scientists spoke about one of the first cases of thrombolytic therapy, which was carried out more than 50 years ago. The patient was Marshal of the USSR Georgy Zhukov, the group of doctors was led by Evgeny Chazov. The clinical case is published in the European Heart Journal. Previously, only their memoirs were known about him.

In the early days of thrombolytic therapy, every successful treatment was considered outstanding. However, only now a group of Russian scientists led by Nikita Lomakin, Chief Cardiologist of the Office of the President of the Russian Federation, received access to the documents and was able to share this unique case.

At that time, the use of fibrinolytic drugs was only at the initial stage, and was not supported by large studies. Even today, their use for patients with progressive ischemic stroke at a time when the therapeutic window is "closing" can be difficult for doctors.

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Georgy Zhukov (then he was 71 years old) was admitted to the neurological department on January 1, 1968 with "stroke" complaints. He was conscious and estimated to be in moderate severity. However, in the first days of hospitalization, the patient's condition began to deteriorate, the doctors agreed that the narrowing of the arteries supplying the brain stem was progressing, which threatened with complications and a poor outcome of the disease.

At Evgeny Chazov's suggestion, it was decided to start antithrombotic therapy to dissolve blood clots in the arteries. It was carried out using intravenous infusions of fibrinolysin, heparin and vitamin K antagonists. The patient's condition improved after two hours, and two days later (January 23), neurological symptoms showed positive dynamics for the first time. The scientists report that laboratory data also showed significant improvement.

Thrombolytic therapy was carried out until the patient was discharged on May 22, 1968. During this time, the symptoms of brain damage showed significant regression. Marshal Zhukov was discharged in a "relatively satisfactory" condition.

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Scientists point out that thrombolytic therapy for ischemic stroke at such a late date poses a dilemma for doctors: on the one hand, such treatment can help, on the other hand, it can provoke a cerebral hemorrhage. Thus, modern therapy with tissue plasminogen activators is usually not prescribed already 3.5 hours after a vascular catastrophe.

The decision of Chazov and colleagues to prescribe vitamin K antagonists along with heparin and fibrinolysin, according to scientists, was bold. They point to the limited choice of doctors of that time and consider their choice fully justified. After successful treatment, Marshal Zhukov lived for more than six years. Lomakin and co-authors write that the presented case is the first documented evidence of such a method of treatment.

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