Table of contents:
Video: Removal Of Appendicitis Linked To Risk Of Parkinson's Disease
Removal of appendicitis linked to risk of Parkinson's disease
People who have had their appendix removed are three times more likely to develop Parkinson's disease, according to a new large-scale American study.
Photo: pixabay.com /
People who have had their appendix removed are three times more likely to develop Parkinson's disease, according to a new large-scale American study. The research will be presented at the Digestive System Diseases Conference, which will be held May 18-21 in San Diego, California, USA.
One of the hallmarks of Parkinson's disease is accumulation of the toxic protein alpha-synuclein, which can lead to degeneration of nerve cells. These clusters, also known as Lewy bodies, are commonly found in the brain cells of patients with Parkinson's disease, causing disease-related movement disorders such as tremors and vestibular disorders. But these protein accumulations in the early stages of Parkinson's disease can also accumulate in the cells that innervate the gastrointestinal tract. This suggests that the gastrointestinal tract may play a role in the development of the disease.
“Recent research into the causes of Parkinson's disease has focused on the role of alpha-synuclein, a protein found in the gastrointestinal tract during the early stages of Parkinson's disease. That's why scientists around the world are studying the gastrointestinal tract, including the appendix, to look for evidence of Parkinson's disease,”said Mohammed Z. Sheriff, lead author of the study at Case University in the US Western Reserve Region.
Previous studies have shown that appendectomy, surgery to remove the appendix, may increase the risk of Parkinson's disease, but the evidence has been controversial.
To shed light on this issue, scientists looked at medical histories and identified patients who underwent an appendix removal, and six months after surgery, they were diagnosed with Parkinson's disease.
From 62218050 case histories from the database, scientists identified 488,190 patients who underwent appendectomy. They also found that 4,470 (0.92%) of them subsequently developed Parkinson's disease, compared with 177,230 (0.29%) of those who did not have their appendix removed.
Thus, the analysis showed that in people who underwent removal of the appendix, the risk of developing Parkinson's disease was 3.19 times higher.
The researchers also found that the risk of developing Parkinson's disease was the same across all age groups, regardless of gender or ethnicity.
“This study shows a clear link between the appendix, or rather removal of the appendix, and Parkinson's disease, but it’s just a link. More research is needed to confirm this link and better understand the mechanisms involved,”said Dr. Sheriff.