Chance For Patients With Inoperable Liver Tumor

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Chance For Patients With Inoperable Liver Tumor
Chance For Patients With Inoperable Liver Tumor

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Video: Regional chemotherapy for liver tumors 2023, February
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Chance for patients with inoperable liver tumor

For the first time in Russia, a new method of treating liver cancer was used - a patient with the third stage of oncological disease underwent radiation embolization. This technology allows to stop tumor growth in almost 90% of patients and increases life expectancy by 4-5 times compared to other methods of treatment.

Chance for patients with inoperable liver tumor
Chance for patients with inoperable liver tumor

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For the first time in Russia, a new method of treating liver cancer was used - a patient with the third stage of cancer was successfully treated with radiation embolization. This technology allows stopping tumor growth in almost 90% of patients and increases life expectancy by 4-5 times compared to other methods of treatment. During the operation, a radionuclide preparation of domestic production was used.

Radioembolization is a method of treating cancer, combining radiation therapy and embolization (cessation of blood supply to a specific part of the organ). A 60-year-old patient with a diagnosis of stage III liver cancer was operated on a few days ago at the Department of X-ray Surgical Diagnostics and Treatment of the A.F. Tsyba - branch of the Federal State Budgetary Institution "NMITs of Radiology". It was impossible to perform radical surgery on him, and radioembolization of the liver became the last hope for stopping the process of tumor growth. Turkish professor Ahmet Murat Dokdok (Anadolu Medical Center In Affilation with Johns Hopkins Medicine), one of the most experienced specialists in this field in the world, was invited to participate in the operation.

The essence of the method is that special glass microspheres (micro-sources of radioactive radiation) containing a radionuclide preparation - yttrium-90 are introduced into the vessels feeding the tumor. It blocks the blood supply to the tumor and destroys it from the inside. At the same time, the surrounding healthy tissues are practically not affected.

“We have been going to this stage for a whole year, a huge amount of work has been done. This is a significant day not only for our center, but for the whole of Russian medicine,”said Academician Andrey Kaprin, Director General of the National Medical Research Center of Radiology. According to him, unlike chemoembolization, in which chemical drugs are injected directly close to the tumor, a special approach is required to the radionuclide. This requires a special training of a doctor, a radiologist, who would properly deal with radionuclide preparations - their storage, delivery, and dosimetry measurement.

At the Center. A.F. Tsyba method of tumor radioembolization using Yttrium-90 is undergoing the first and second phases of clinical trials. Previously, the patient underwent a diagnostic operation, during which technetium was administered to the patient instead of microspheres with Yttrium-90 radionuclides. This was done in order to assess the condition of the liver and the structure of blood vessels and determine if there is a danger of damaging healthy tissues or other organs. And also to determine the volume of the tumor, which we will fill with microspheres.

In world practice, the method of radioembolization is known, but little is available due to the extreme complexity of execution and high cost of drugs. In addition, the drug's short half-life makes delivery difficult. The production of domestic microspheres based on the yttrium-90 radionuclide, launched jointly by the Ministry of Health of the Russian Federation, State Corporation Rosatom, the Russian company BEBIG, and the National Medical Research Center of Radiology, gave a chance to introduce radioembolization into practical Russian health care. The release of microspheres by domestic manufacturers will significantly reduce the cost of radioembolization. And, according to the head. Department of X-ray Surgical Methods of Diagnosis and Treatment of the A.F. Tsyba Valeria Kucherova, doctors very much hope that such operations will become a routine practice and will be included in the program of state guarantees for free medical care.

About 8 thousand new cases of liver cancer are detected in Russia every year (in 5-6 people per 100 thousand of the population). In addition, the liver is the most vulnerable human organ in cancer. 70–75% of all cancers lead to metastatic lesions of the liver. The main method of treatment for this type of cancer is radical surgery is possible only in 20% of patients. In patients with an inoperable tumor (larger than 5 cm), chemotherapy is used to prolong life by only 6-18 months.

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