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Video: Statin Therapy Fails In Half Of Patients
Statin therapy fails in half of patients
In half of patients on statins to prevent heart disease, the level of "bad cholesterol" does not decrease sufficiently after two years of treatment. The cause of this problem is unknown, in part it may be due to irregular medications.
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In half of patients on statins to prevent heart disease, the level of "bad cholesterol" does not decrease sufficiently after two years of treatment. This is stated in a study published in the journal Heart.
The current goal of such therapy is to reduce low-density lipoprotein levels by 40 percent or more. But in the new study, 51 percent of the participants had a “suboptimal” response to treatment, meaning a decrease of less than 40 percent. The scientific work used data from 165,411 people who received statins from 1990 to 2016.
Patients who did not achieve their treatment goals had a 22 percent increased risk of developing cardiovascular disease compared to those who responded well.
"The study contributes to the debate about the effectiveness of statins and highlights the need for personalized therapy for elevated levels of harmful lipids," they write.
Metin Avkiran, medical director of the British Heart Foundation, said: “While this study showed that not everyone prescribed statins achieves treatment goals, it does not explain why this happened. Perhaps people were not given the maximum potency statins, or they were not taking them as prescribed."
Professor Helen Stokes-Lampard, Chair of the Royal College of General Practitioners, noted that there is substantial evidence for the efficacy and safety of statins, although some controversy remains. The prescribing physician has to rely on how patients take their medication.