Breast Cancer Risk Is Linked To Biological Age

Table of contents:

Breast Cancer Risk Is Linked To Biological Age
Breast Cancer Risk Is Linked To Biological Age

Video: Breast Cancer Risk Is Linked To Biological Age

Отличия серверных жестких дисков от десктопных
Video: Major Causes of Breast Cancer | Breast cancer risk factors | Explained by Dr. Manish Singhal 2023, February
Anonim

Breast cancer risk is linked to biological age

According to the data obtained, every additional five years of biological age to chronological age increases the growth of the chances of developing breast cancer by 15%.

Breast cancer risk is linked to biological age
Breast cancer risk is linked to biological age

Photo: roche.com /

Biological age - an estimate of a person's age based on DNA research - is linked to the future development of breast cancer, according to scientists at the National Institute of Environmental Health Sciences (NIEHS). The study is published online in the Journal of the National Cancer Institute.

The researchers hypothesized a link between biological age and exposure to environmental factors, which may be a useful indicator of the risk of developing diseases. They analyzed DNA from blood samples provided by participants in a specially designed study to identify external and genetic risk factors for breast cancer Sister Study (2,764 women, none of whom had cancer at the time of blood collection), conducted under the direction of NIEHS.

To determine biological age, the research team measured DNA methylation, a chemical modification of DNA that is part of the normal aging process. If the biological age is ahead of the chronological (actual) age, this is called "age acceleration".

“If you look at a group of people of the same age, some of them may be perfectly healthy and others may not. This variability in health status may be better reflected by biological age than by chronological age,”explained lead author Jacob Kresovich.

Since age is the leading risk factor for breast cancer, accelerating age may be associated with a higher risk of developing this type of cancer. Indeed, according to the data obtained, every additional five years of biological age to the chronological age increases the increase in the chances of developing breast cancer by 15%.

“We found that if your biological age is older than your chronological age, your risk of breast cancer increases. The converse is also true. If your biological age is younger than your chronological age, you can lower your risk of developing breast cancer. However, we do not yet know how influences and lifestyle factors can affect biological age or whether this process can be reversed,”said Jack Taylor, a member of the research team.

This research is epigenetic (epigenetics is the field that studies how biochemical processes turn individual genes on or off without affecting the DNA sequence). Using DNA methylation to measure biological age will help better understand who is at risk of developing cancer and other age-related diseases, scientists say.

Popular by topic