Drug Interactions Everyone Should Know About

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Drug Interactions Everyone Should Know About
Drug Interactions Everyone Should Know About

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Video: Drug Interactions | 5 Tips You Should Do To Avoid Them 2023, February
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Drug Interactions Everyone Should Know About

Certain combinations of drugs that are used to treat different diseases affect each other and cause side effects. The tablets can also interact with food, drinks, and herbal products. Below are some of the common combinations to be wary of.

Drug Interactions Everyone Should Know About
Drug Interactions Everyone Should Know About

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Certain combinations of drugs that are used to treat different diseases affect each other and cause side effects. The tablets can also interact with food, drinks, and herbal products. Below are some of the common combinations to be wary of.

1. Statins and grapefruit juice. Medications of the statin group (drugs that lower blood cholesterol levels) are prescribed to prevent myocardial infarction and stroke.

People who are aware of their high cholesterol levels often try to increase the amount of fruits and vegetables in their diet. Therefore, it is important to know that grapefruit juice can slow down the breakdown of statins in the body, thereby increasing their levels in the blood and, accordingly, increasing the side effects.

2. Warfarin and green leafy vegetables. Taking warfarin (a medicine for preventing and treating blood clots) requires regular blood tests to make sure that the dose is correct.

Supplements and foods containing vitamin K (green leafy vegetables and green tea) speed up the elimination of warfarin from the body, with serious consequences such as an increased risk of stroke or deep vein thrombosis. The attending physician should be aware of changes in the patient's diet to adjust the dosage of warfarin.

3. Antidepressants and ibuprofen. Taking SSRI antidepressants (selective serotonin reuptake inhibitors) along with NSAIDs (such as a combination of citalopram and ibuprofen) may increase the risk of internal bleeding, usually gastric bleeding. Symptoms include dark stools, stomach cramps, fatigue, blood vomiting, and a feeling of weakness or dizziness.

This side effect can be avoided by administering drugs to protect the stomach, in particular lansoprazole. However, when choosing such a medication, its potential interactions with antidepressants should be considered.

4. Metronidazole and alcohol. Recommendations not to consume alcohol while taking antibiotics, especially metronidazole, can cause severe nausea and vomiting. You must wait at least two days after the end of the course for the complete removal of the drug from the body.

5. St. John's wort and birth control pills. Many people mistakenly believe that herbal medicines are harmless. For example, a number of drugs based on St. John's wort (or St. John's wort) are intended to treat the symptoms of mild depression. St. John's wort speeds up the disintegration time of many drugs, thereby reducing their effectiveness. Thus, taking medications with St. John's wort and birth control pills increases the likelihood of pregnancy.

The UK's Medicines and Healthcare products Regulatory Agency recommends avoiding the combination of St. John's wort and COCs.

6. Calcium supplements and other medications. Bones become weaker as we age, so calcium and vitamin D supplements are prescribed to strengthen them and prevent fractures. While these supplements are clearly beneficial, they can interfere with the body's absorption of other drugs. These include some antibiotics, drugs to prevent malaria, and to treat hypothyroidism. There should be an interval of 2-6 hours between the use of calcium and other medicines.

It is also necessary to understand that taking medications should not be stopped on their own, before visiting a doctor. Any sudden change in treatment can lead to more serious consequences than any of the listed interactions.

Based on materials from The Conversation

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