Sugar Substitute Found Anti-cancer Potential

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Sugar Substitute Found Anti-cancer Potential
Sugar Substitute Found Anti-cancer Potential

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Sugar substitute found anti-cancer potential

Mannose, a well-known sugar substitute, can slow the growth of several types of tumors and enhance the effects of chemotherapy. A new study in mice is raising the question of whether mannose sugar can be used to treat cancer.

Sugar substitute found anti-cancer potential
Sugar substitute found anti-cancer potential

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Mannose, a well-known sugar substitute, can slow the growth of several types of tumors and enhance the effects of chemotherapy. A new study in mice is raising the question of whether mannose sugar can be used to treat cancer. Scientific work published in the journal Nature.

More glucose is needed for tumor growth than is normally consumed by healthy tissue. However, it is very difficult to control the amount of glucose in the body with diet alone. In this study, scientists found that mannose can reduce the amount of sugar that cancer cells can use.

“Tumors need a lot of glucose to grow, so limiting the amount of glucose they can use should slow the progression of cancer. The problem is that normal tissues also need glucose, so we cannot completely remove it from the body. In our study, we determined a dosage of mannose that can block a certain amount of glucose to slow tumor growth in mice, but not enough to damage normal tissue. We hope that finding the ideal balance means that in the future, mannose can be given to cancer patients to enhance the effects of chemotherapy without compromising their overall health,”said Professor Kevin Ryan, lead author of the study at the Beatson Institute in Britain. cancer research (Cancer Research UK Beatson Institute).

First, the researchers conducted experiments on mice with cancer of the pancreas, lung and skin. Mannose was added to their drinking water and given orally. The scientists then found that as a result, tumor growth was significantly slowed down without causing any noticeable side effects.

To test how mannose affects cancer treatment, the mice were treated with cisplatin and doxorubicin, two widely used chemotherapy drugs. They found that mannose enhances the effects of chemotherapy, slows tumor growth, shrinks tumor size, and even increases the lifespan of some mice.

Several other types of cancer have also been investigated, including leukemia, osteosarcoma, ovarian and bowel cancers. Researchers grew cancer cells in a laboratory and then treated them with mannose to determine how it affected their growth.

Some cells responded well to treatment, while others did not. It has also been found that the presence of an enzyme that breaks down mannose in cells is a good indicator of treatment efficacy.

Professor Kevin Ryan added that the next step should be to answer the question of why such treatment only affects some cells, in order to find out which patients can benefit most from this type of treatment.

Mannose is sometimes used to treat urinary tract infections, but its long-term effects have not yet been investigated.

“While these results are very promising for some cancer treatments, the treatment has not yet been tested in humans. Patients should not try to treat with mannose on their own, as there is a real risk of side effects that have not yet been investigated. In this case, you should consult with your doctor before drastically changing your diet or taking new supplements,”says Martin Ledwick of the UK Institute for Cancer Research.

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