Up To 40% Of Ischemic Stroke Cases Can Be Genetically Related

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Up To 40% Of Ischemic Stroke Cases Can Be Genetically Related
Up To 40% Of Ischemic Stroke Cases Can Be Genetically Related

Video: Up To 40% Of Ischemic Stroke Cases Can Be Genetically Related

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Video: Ischemic Stroke | Lisa Klein 2023, January
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Up to 40% of ischemic stroke cases can be genetically related

Russian scientists have developed a set of reagents to determine the individual genetic risk of ischemic stroke. The test to determine the susceptibility to stroke was tested in several scientific centers, based on the results obtained, an original method for calculating individual genetic risks was developed and a patent was obtained.

Up to 40% of ischemic stroke cases can be genetically related
Up to 40% of ischemic stroke cases can be genetically related

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Russian scientists have developed a set of reagents to determine the individual genetic risk of ischemic stroke. The test to determine the susceptibility to stroke was tested in several scientific centers, based on the results obtained, an original method for calculating individual genetic risks was developed and a patent was obtained.

On October 29, many countries around the world celebrated World Stroke Day, which the World Health Organization declared a global epidemic.

Stroke is a multifactorial disease. According to the WHO classification, risk factors include modifiable factors (unhealthy lifestyle and related diseases), a number of cardiovascular and endocrine diseases, and non-modifiable factors (heredity, age, gender). At the same time, a stroke is rapidly getting younger, affecting people 35-40 years old. Scientists are sure that "young strokes" are associated not only with an incorrect lifestyle - one of the main risk factors is hereditary predisposition. According to various sources, up to 40% of cases of the disease can be genetically determined. Therefore, one of the tasks of stroke prevention today is the identification of risk groups with a hereditary predisposition to the disease at the pre-symptomatic stage.

Over the past 10 years, serious research has been carried out around the world on the hereditary component of stroke, namely the genetic factors that determine the risk of its development. Articles by German and American scientists about research on the FOXF2 gene, whose mutations, according to the authors, can directly affect the risk of stroke, were published in 2016 in the journal Lancet Neurology. Previously, scientists were able to find that the likelihood of the appearance of the disease is associated with genes whose products are involved in atherogenesis, and genes that affect the process of blood coagulation.

“Stroke is a multifactorial disease associated with the functioning of various body systems, initially determined by heredity,” says Vitaly Korchagin, an employee of the research group for the development of new methods for detecting genetic polymorphisms of the Central Research Institute of Epidemiology of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare. "And the more analyzes we carry out, the greater the contribution of the genetic component to early stroke we see." If a person knows about their genetic predisposition to stroke, leads a healthy lifestyle, monitors health indicators and controls risk factors, then the likelihood of developing the disease decreases, says Korchagin.

Based on world research, researchers from the Central Research Institute of Epidemiology of Rospotrebnadzor have developed a set of reagents that allows you to determine the individual genetic risk of ischemic stroke. The test was tested in several scientific centers, based on the results obtained, an original method for calculating individual genetic risks was developed and a patent was obtained. " Currently, the test to determine the genetic predisposition to stroke is undergoing registration with the Federal Service for Surveillance in Healthcare, we are confident that its introduction into clinical practice will make a big step in the individualized prevention of ischemic stroke," Korchagin notes.

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