A Substance Found In Vegetables That Can Prolong Life By 10%

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A Substance Found In Vegetables That Can Prolong Life By 10%
A Substance Found In Vegetables That Can Prolong Life By 10%

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A substance found in vegetables that can prolong life by 10%

Natural dye is able to selectively and effectively kill senescent cells, or at least reduce their secretions and reduce the level of inflammatory proteins.

A substance found in vegetables that can prolong life by 10%
A substance found in vegetables that can prolong life by 10%

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Scientists from the Scripps Research Institute and the Mayo Clinic have studied the effects of the natural dye fisetin in the fight against aging. The results of their research were published on September 29 in the journal EBioMedicine. The authors expect the substance to extend life by about 10%.

“We are looking for drugs that can kill damaged senescent cells that are very harmful to the body and accumulate in it as we get older. Fisetin turns out to be a natural product that can selectively and effectively kill aging cells, or at least reduce their secretions and inflammatory proteins,”says Laura Niedernhofer, director of the Institute for the Biology of Aging and Metabolism at the University of Minnesota. on the Biology of Aging and Metabolism at the University of Minnesota).

Cells age when they reach a certain level of damage as a person ages. The immune system of a young person is able to cleanse the body of aging cells, but the older the person, the more difficult the cleansing process is. As senescent cells accumulate, they can cause inflammation and release enzymes that can destroy tissue. Fisetin belongs to senolytics, substances that can eliminate aging cells. To test if fisetin helps eliminate damaged cells, the researchers gave fisetin to aged mice.

“Remarkably, the lifespan and healthy lifespan of these mice have increased by 10%. The duration of a healthy life is the period of a person's life when he is alive and well, and not just alive. In terms of dose, the question is whether we can give a smaller dose or not so often. This is a theoretical advance on the frequency of use of these drugs that can eliminate senescent cells,”says Paul Robbins, study author at the University of Minnesota.

The researchers also tested the effects of fisetin on human adipose tissue in a laboratory setting to see how the drug would interact with human cells, not just mice. Because it was able to reduce the number of senescent cells in human adipose tissue, scientists believe that it is likely that fisetin will work in humans as well. However, the amount of fisetin in fruits and vegetables is not enough to effectively eliminate aging cells - scientists have yet to work out the optimal dosage.

An article published in June in the journal Nature Medicine in June said that fisetin may improve physical functioning in old age, and an August article in the journal Aging Cell argued that senescent cells may be associated with Alzheimer's disease. Fisetin is currently in clinical trials at the Mayo Clinic and may be available to combat senescent cells in the next couple of years.

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